PRKCSH Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P14314 |
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Clone Names | 100311263 |
Gene ID | 5589 |
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Other Names | Glucosidase 2 subunit beta, 80K-H protein, Glucosidase II subunit beta, Protein kinase C substrate 601 kDa protein heavy chain, PKCSH, PRKCSH, G19P1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PRKCSH {ECO:0000303|PubMed:28375157, ECO:0000312|HGNC:HGNC:9411} |
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Function | Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). |
Cellular Location | Endoplasmic reticulum {ECO:0000255|PROSITE- ProRule:PRU10138, ECO:0000305|PubMed:10929008} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the beta-subunit of glucosidase II, anN-linked glycan-processing enzyme in the endoplasmic reticulum(ER). This protein is an acidic phospho-protein known to be asubstrate for protein kinase C. Mutations in this gene have beenassociated with the autosomal dominant polycystic liver disease(PCLD). Alternatively spliced transcript variants encoding distinctisoforms have been observed.
References
Hoverfelt, A., et al. Diabetologia 53(9):1903-1907(2010)Waanders, E., et al. Clin. Genet. 78(1):47-56(2010)van Keimpema, L., et al. Liver Int. (2010) In press :Yang, A.M., et al. Dig. Dis. Sci. 55(3):815-819(2010)Gao, H., et al. Hum. Mol. Genet. 19(1):16-24(2010)
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