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PRKCSH Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P14314
Clone Names 100311263
Additional Information
Gene ID 5589
Other Names Glucosidase 2 subunit beta, 80K-H protein, Glucosidase II subunit beta, Protein kinase C substrate 601 kDa protein heavy chain, PKCSH, PRKCSH, G19P1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRKCSH {ECO:0000303|PubMed:28375157, ECO:0000312|HGNC:HGNC:9411}
Function Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).
Cellular Location Endoplasmic reticulum {ECO:0000255|PROSITE- ProRule:PRU10138, ECO:0000305|PubMed:10929008}
Research Areas
Citations (0)
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Background

This gene encodes the beta-subunit of glucosidase II, anN-linked glycan-processing enzyme in the endoplasmic reticulum(ER). This protein is an acidic phospho-protein known to be asubstrate for protein kinase C. Mutations in this gene have beenassociated with the autosomal dominant polycystic liver disease(PCLD). Alternatively spliced transcript variants encoding distinctisoforms have been observed.

References

Hoverfelt, A., et al. Diabetologia 53(9):1903-1907(2010)Waanders, E., et al. Clin. Genet. 78(1):47-56(2010)van Keimpema, L., et al. Liver Int. (2010) In press :Yang, A.M., et al. Dig. Dis. Sci. 55(3):815-819(2010)Gao, H., et al. Hum. Mol. Genet. 19(1):16-24(2010)

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$ 277.78
Cat# BP19155a
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