|Other Names||V-type proton ATPase subunit F, V-ATPase subunit F, V-ATPase 14 kDa subunit, Vacuolar proton pump subunit F, ATP6V1F, ATP6S14, VATF|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.|
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This gene encodes a component of vacuolar ATPase(V-ATPase), a multisubunit enzyme that mediates acidification ofeukaryotic intracellular organelles. V-ATPase dependent organelleacidification is necessary for such intracellular processes asprotein sorting, zymogen activation, receptor-mediated endocytosis,and synaptic vesicle proton gradient generation. V-ATPase iscomposed of a cytosolic V1 domain and a transmembrane V0 domain.The V1 domain consists of three A and three B subunits, two Gsubunits plus the C, D, E, F, and H subunits. The V1 domaincontains the ATP catalytic site. The V0 domain consists of fivedifferent subunits: a, c, c', c', and d. Additional isoforms ofmany of the V1 and V0 subunit proteins are encoded by multiplegenes or alternatively spliced transcript variants. This encodedprotein is the V1 domain F subunit protein.
Supino, R., et al. Ann. N. Y. Acad. Sci. 1171, 606-616 (2009) :Smith, A.N., et al. J. Bioenerg. Biomembr. 40(4):371-380(2008)Morel, N. Biol. Cell 95(7):453-457(2003)Smith, A.N., et al. Mol. Cell 12(4):801-803(2003)Kawasaki-Nishi, S., et al. FEBS Lett. 545(1):76-85(2003)
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