|Other Names||Xylosyltransferase 2, Peptide O-xylosyltransferase 1, Xylosyltransferase II, XT-II, XylT-II, XYLT2, XT2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the formation of heparan sulfate and chondroitin sulfate proteoglycans (PubMed:26027496). Probably catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes (By similarity). Its enzyme activity has not been demonstrated.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Widely expressed. Expressed at higher level in kidney and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an isoform ofxylosyltransferase, which belongs to a family ofglycosyltransferases. This enzyme transfers xylose from UDP-xyloseto specific serine residues of the core protein and initiates thebiosynthesis of glycosaminoglycan chains in proteoglycans includingchondroitin sulfate, heparan sulfate, heparin and dermatan sulfate.The enzyme activity, which is increased in scleroderma patients, isa diagnostic marker for the determination of sclerotic activity insystemic sclerosis.
Condac, E., et al. Glycobiology 19(8):829-833(2009)Casanova, J.C., et al. Biochem. Biophys. Res. Commun. 383(1):4-10(2009)Ponighaus, C., et al. Am. J. Hypertens. 22(4):432-436(2009)Ambrosius, M., et al. Clin. Biochem. 42 (1-2), 1-4 (2009) :Hendig, D., et al. Clin. Chim. Acta 398 (1-2), 90-94 (2008) :
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