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XYLT2 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9H1B5
Clone Names 100318278
Additional Information
Gene ID 64132
Other Names Xylosyltransferase 2, Peptide O-xylosyltransferase 1, Xylosyltransferase II, XT-II, XylT-II, XYLT2, XT2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name XYLT2
Synonyms XT2
Function Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein.
Cellular Location Golgi apparatus membrane; Single- pass type II membrane protein. Secreted
Tissue Location Widely expressed. Expressed at higher level in kidney and pancreas.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is an isoform ofxylosyltransferase, which belongs to a family ofglycosyltransferases. This enzyme transfers xylose from UDP-xyloseto specific serine residues of the core protein and initiates thebiosynthesis of glycosaminoglycan chains in proteoglycans includingchondroitin sulfate, heparan sulfate, heparin and dermatan sulfate.The enzyme activity, which is increased in scleroderma patients, isa diagnostic marker for the determination of sclerotic activity insystemic sclerosis.

References

Condac, E., et al. Glycobiology 19(8):829-833(2009)Casanova, J.C., et al. Biochem. Biophys. Res. Commun. 383(1):4-10(2009)Ponighaus, C., et al. Am. J. Hypertens. 22(4):432-436(2009)Ambrosius, M., et al. Clin. Biochem. 42 (1-2), 1-4 (2009) :Hendig, D., et al. Clin. Chim. Acta 398 (1-2), 90-94 (2008) :

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$ 277.78
Cat# BP19159a
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