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CPSF5 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O43809
Clone Names 5082555
Additional Information
Gene ID 11051
Other Names Cleavage and polyadenylation specificity factor subunit 5, Cleavage and polyadenylation specificity factor 25 kDa subunit, CFIm25, CPSF 25 kDa subunit, Nucleoside diphosphate-linked moiety X motif 21, Nudix motif 21, Pre-mRNA cleavage factor Im 25 kDa subunit, NUDT21, CFIM25, CPSF25, CPSF5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1915b was selected from the N-term region of human CPSF5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NUDT21
Synonyms CFIM25, CPSF25, CPSF5
Function Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.
Cellular Location Nucleus. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles
Research Areas
Citations (0)

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CPSF5 is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. CPSF5 is the 25kD subunit of the protein complex, which is composed of four polypeptides.


Dettwiler, S., et al., J. Biol. Chem. 279(34):35788-35797 (2004).Lehner, B., et al., Genome Res. 14(7):1315-1323 (2004).de Vries, H., et al., EMBO J. 19(21):5895-5904 (2000).Ruegsegger, U., et al., Mol. Cell 1(2):243-253 (1998).Ruegsegger, U., et al., J. Biol. Chem. 271(11):6107-6113 (1996).

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$ 80.00
Cat# BP1915b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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