HOXB13 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q92826 |
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Clone Names | 100517022 |
Gene ID | 10481 |
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Other Names | Homeobox protein Hox-B13, HOXB13 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | HOXB13 |
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Function | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536). |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a transcription factor that belongs tothe homeobox gene family. Genes of this family are highly conservedamong vertebrates and essential for vertebrate embryonicdevelopment. This gene has been implicated to play a role in fetalskin development and cutaneous regeneration. In mice, a similargene was shown to exhibit temporal and spatial colinearity in themain body axis of the embryo, but was not expressed in thesecondary axes, which suggests functions in body patterning alongthe axis. This gene and other HOXB genes form a gene cluster atchromosome the 17q21-22 region.
References
McMullin, R.P., et al. Proc. Natl. Acad. Sci. U.S.A. 107(1):98-103(2010)Kim, Y.R., et al. Mol. Cancer 9, 124 (2010) :Norris, J.D., et al. Mol. Cell 36(3):405-416(2009)Goetz, M.P., et al. Clin. Cancer Res. 14(18):5864-5868(2008)Rodriguez, B.A., et al. Carcinogenesis 29(7):1459-1465(2008)
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