|Other Names||Mitochondrial import inner membrane translocase subunit Tim10, TIMM10, TIM10|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|
|Cellular Location||Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side|
|Tissue Location||Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
TIMM10 belongs to a family of evolutionarily conservedproteins that are organized in heterooligomeric complexes in themitochondrial intermembrane space. These proteins mediate theimport and insertion of hydrophobic membrane proteins into themitochondrial inner membrane.
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Carey, K.A., et al. Pathol. Int. 56(5):246-255(2006)Webb, C.T., et al. Mol. Cell 21(1):123-133(2006)Muhlenbein, N., et al. J. Biol. Chem. 279(14):13540-13546(2004)Allen, S., et al. J. Biol. Chem. 278(40):38505-38513(2003)
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