|Other Names||Desert hedgehog protein, DHH, HHG-3, Desert hedgehog protein N-product, Desert hedgehog protein C-product, DHH|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.|
|Cellular Location||Desert hedgehog protein N-product: Cell membrane; Lipid-anchor; Extracellular side. Note=The N-terminal peptide remains associated with the cell surface.|
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This gene encodes a member of the hedgehog family. Thehedgehog gene family encodes signaling molecules that play animportant role in regulating morphogenesis. This protein ispredicted to be made as a precursor that is autocatalyticallycleaved; the N-terminal portion is soluble and contains thesignalling activity while the C-terminal portion is involved inprecursor processing. More importantly, the C-terminal productcovalently attaches a cholesterol moiety to the N-terminal product,restricting the N-terminal product to the cell surface andpreventing it from freely diffusing throughout the organism.Defects in this protein have been associated with partial gonadaldysgenesis (PGD) accompanied by minifascicular polyneuropathy. Thisprotein may be involved in both male gonadal differentiation andperineurial development.
Chinchilla, P., et al. Cell Cycle 9(3):570-579(2010)Bishop, B., et al. Nat. Struct. Mol. Biol. 16(7):698-703(2009)Hegde, G.V., et al. Mol. Cancer Res. 6(12):1928-1936(2008)Nakamura, M., et al. Fukuoka Igaku Zasshi 99(5):102-106(2008)Canto, P., et al. Mol. Hum. Reprod. 11(11):833-836(2005)
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