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UBASH3A Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P57075
Clone Names 90713226
Peptide ID 90713226
Additional Information
Gene ID 53347
Other Names Ubiquitin-associated and SH3 domain-containing protein A, Cbl-interacting protein 4, CLIP4, Suppressor of T-cell receptor signaling 2, STS-2, T-cell ubiquitin ligand 1, TULA-1, UBASH3A, STS2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBASH3A
Synonyms STS2
Function Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
Cellular Location Cytoplasm. Nucleus.
Tissue Location Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.
Research Areas
Citations (0)

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Background

UBASH3A interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface.

References

Hinks, A., et al. Ann. Rheum. Dis. (2010) In press :Stahl, E.A., et al. Nat. Genet. 42(6):508-514(2010)Jin, Y., et al. N. Engl. J. Med. 362(18):1686-1697(2010)Barrett, J.C., et al. Nat. Genet. 41(6):703-707(2009)Smyth, D.J., et al. N. Engl. J. Med. 359(26):2767-2777(2008)

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$ 80.00
Cat# BP19175c
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