PANX2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96RD6 |
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Clone Names | 110617186 |
Gene ID | 56666 |
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Other Names | Pannexin-2, PANX2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PANX2 (HGNC:8600) |
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Function | Ion channel with a slight anion preference (PubMed:36973289). Also able to release ATP (PubMed:36869038). Plays a role in regulating neurogenesis and apoptosis in keratinocytes (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351} Golgi apparatus membrane {ECO:0000250|UniProtKB:Q6IMP4}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6IMP4}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Note=Localizes to Golgi apparatus and endoplasmic reticulum in multipotential neural stem and progenitor cells and to plasma membrane in terminally differentiated neurons. {ECO:0000250|UniProtKB:Q6IMP4} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the innexinfamily. Innexin family members are the structural components of gapjunctions. This protein and pannexin 1 are abundantly expressed incentral nervous system (CNS) and are coexpressed in variousneuronal populations. Studies in Xenopus oocytes suggest that thisprotein alone and in combination with pannexin 1 may form celltype-specific gap junctions with distinct properties. Multipletranscript variants encoding different isoforms have been found forthis gene.
References
Ambrosi, C., et al. J. Biol. Chem. 285(32):24420-24431(2010)Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Lai, C.P., et al. Oncogene 28(49):4402-4408(2009)Wu, C., et al. Proteomics 7(11):1775-1785(2007)
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