|Other Names||Bestrophin-3, Vitelliform macular dystrophy 2-like protein 3, BEST3, VMD2L3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Present in skeletal muscle and weakly in brain, spinal cord, bone marrow and retina|
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Provided below are standard protocols that you may find useful for product applications.
BEST3 belongs to the bestrophin family of anion channels,which includes BEST1 (MIM 607854), the gene mutant in vitelliformmacular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes,BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins aretransmembrane (TM) proteins that share a homology region containinga high content of aromatic residues, including an invariantarg-phe-pro (RFP) motif. The bestrophin genes share a conservedgene structure, with almost identical sizes of the 8 RFP-TMdomain-encoding exons and highly conserved exon-intron boundaries.Each of the 4 bestrophin genes has a unique 3-prime end of variablelength (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al.,2003 [PubMed 12907679]).
Marsey, L.L., et al. J. Physiol. (Lond.) 587 (PT 10), 2211-2224 (2009) :Qu, Z.Q., et al. J. Biol. Chem. 282(24):17460-17467(2007)Tsunenari, T., et al. J. Biol. Chem. 278(42):41114-41125(2003)Stohr, H., et al. Eur. J. Hum. Genet. 10(4):281-284(2002)Marquardt, A., et al. Hum. Mol. Genet. 7(9):1517-1525(1998)
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