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RCC1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P18754
Clone Names 5083153
Peptide ID 5083153
Additional Information
Gene ID 1104
Other Names Regulator of chromosome condensation, Cell cycle regulatory protein, Chromosome condensation protein 1, RCC1, CHC1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1919a was selected from the N-term region of human RCC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RCC1
Synonyms CHC1
Function Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly.
Cellular Location Nucleus. Cytoplasm. Note=Becomes dispersed throughout the cytoplasm during mitosis
Research Areas
Citations (0)

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RCC1 promotes the exchange of Ran-bound GDP by GTP. It is involved in the regulation of onset of chromosome condensation in the S phase. RCC1 binds to chromatin. The RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Patients with Raynaud disease produce antibodies that bind to RCC1.


Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135 (2004).Li, H.Y., et al., Genes Dev. 18(5):512-527 (2004).Cushman, I., et al., Mol. Biol. Cell 15(1):245-255 (2004).Moore, W., et al., Curr. Biol. 12(16):1442-1447 (2002).Nemergut, M.E., et al., J. Biol. Chem. 277(20):17385-17388 (2002).

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$ 80.00
Cat# BP1919a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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