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Mouse Sin3a Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q60520
Clone Names 110919028
Peptide ID 110919028
Additional Information
Gene ID 20466
Other Names Paired amphipathic helix protein Sin3a, Histone deacetylase complex subunit Sin3a, Transcriptional corepressor Sin3a, Sin3a, Kiaa4126
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Sin3a
Synonyms Kiaa4126
Function Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation.
Cellular Location Nucleus. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L.
Tissue Location Widely expressed. Highest levels in testis, lung and thymus
Research Areas
Citations (0)

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Sin3a acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3A to DNA. Acts as a corepressor for REST.


Baltus, G.A., et al. J. Biol. Chem. 284(11):6998-7006(2009)Anderson, D.M., et al. Dev. Dyn. 238(3):572-580(2009)Chang, S., et al. J. Immunol. 181(12):8372-8381(2008)van Oevelen, C., et al. Mol. Cell 32(3):359-370(2008)Wilkinson, D.S., et al. Mol. Cell. Biol. 28(6):1988-1998(2008)

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$ 80.00
Cat# BP19223b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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