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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Mouse Casc5 Antibody (C-term) Blocking Peptide   

Mouse Casc5 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q66JQ7
Clone Names 110919044
Peptide ID 110919044
Additional Information
Other Names Protein CASC5, Cancer susceptibility candidate gene 5 protein homolog, Kinetochore-null protein 1, Casc5, Knl1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Casc5
Synonyms Knl1
Function Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Directly links spindle checkpoint proteins BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (By similarity).
Cellular Location Nucleus. Chromosome, centromere, kinetochore. Note=Weakly expressed in interphase nuclei. Expression increases from prophase to late anaphase, but greatly diminishes from the telophase and cytokinesis to early G1 phase of cell cycle (By similarity) EMBL; AL772264; CAM45955.1; -; Genomic_DNA EMBL; BC080815; AAH80815.1; -; mRNA EMBL; AK009772; BAB26494.1; -; mRNA EMBL; AK033132; BAC28167.2; -; mRNA UniGene; Mm.202518; - UniGene; Mm.392877; - ProteinModelPortal; Q66JQ7; - SMR; Q66JQ7; - IntAct; Q66JQ7; 15 MINT; MINT-8174094; - STRING; 10090.ENSMUSP00000028802; - iPTMnet; Q66JQ7; - PhosphoSitePlus; Q66JQ7; - EPD; Q66JQ7; - MaxQB; Q66JQ7; - PaxDb; Q66JQ7; - PRIDE; Q66JQ7; - Ensembl; ENSMUST00000028799; ENSMUSP00000028799; ENSMUSG00000027326 UCSC; uc008ltb.1; mouse MGI; MGI:1923714; Casc5 eggNOG; ENOG410IF9C; Eukaryota eggNOG; ENOG410XZXJ; LUCA GeneTree; ENSGT00410000025918; - HOGENOM; HOG000246954; - HOVERGEN; HBG080986; - InParanoid; Q66JQ7; - Reactome; R-MMU-2467813; Separation of Sister Chromatids Reactome; R-MMU-2500257; Resolution of Sister Chromatid Cohesion Reactome; R-MMU-5663220; RHO GTPases Activate Formins Reactome; R-MMU-606279; Deposition of new CENPA-containing nucleosomes at the centromere Reactome; R-MMU-68877; Mitotic Prometaphase PRO; PR:Q66JQ7; - Proteomes; UP000000589; Chromosome 2 Bgee; ENSMUSG00000027326; - CleanEx; MM_CASC5; - ExpressionAtlas; Q66JQ7; baseline and differential Genevisible; Q66JQ7; MM GO; GO:0001669; C:acrosomal vesicle; ISO:MGI GO; GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell GO; GO:0005737; C:cytoplasm; ISO:MGI GO; GO:0070062; C:extracellular exosome; ISO:MGI GO; GO:0005654; C:nucleoplasm; ISO:MGI GO; GO:0005634; C:nucleus; ISO:MGI GO; GO:0008608; P:attachment of spindle microtubules to kinetochore; ISO:MGI GO; GO:0051301; P:cell division; IEA:UniProtKB-KW GO; GO:0007067; P:mitotic nuclear division; IEA:UniProtKB-KW GO; GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB GO; GO:0034501; P:protein localization to kinetochore; ISO:MGI 1: Evidence at protein level; Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition; Complete proteome; Kinetochore; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat CHAIN 1 1612 Protein CASC5 /FTId=PRO_0000235983 REPEAT 723 827 1 REPEAT 923 1027 2 REGION 723 1027 2 X 104 AA approximate repeats MOTIF 1577 1590 Nuclear localization signal MOD_RES 32 32 Phosphoserine {ECO:0000250|UniProtKB:Q8NG31} MOD_RES 60 60 Phosphoserine {ECO:0000250|UniProtKB:Q8NG31} MOD_RES 538 538 Phosphoserine {ECO:0000250|UniProtKB:Q8NG31} MOD_RES 540 540 Phosphothreonine {ECO:0000250|UniProtKB:Q8NG31} MOD_RES 794 794 Phosphoserine MOD_RES 878 878 Phosphoserine {ECO:0000250|UniProtKB:Q8NG31} MOD_RES 1243 1243 Phosphoserine {ECO:0000250|UniProtKB:Q8NG31} MOD_RES 1464 1464 Phosphoserine {ECO:0000250|UniProtKB:Q8NG31} CONFLICT 128 128 D -> G (in Ref. 2; AAH80815) CONFLICT 375 375 H -> R (in Ref. 2; AAH80815) CONFLICT 1151 1151 P -> L (in Ref. 2; AAH80815) SEQUENCE 1612 AA; 179337 MW; A9BE2BB20E008621 CRC64; MDGVYSEANE ENDNTQRPVR RQHSSILKPP RSPLQDLKCG NQTNQEPNPP RKRKSSRRVS FADTIKVFQT ESHMKTERNS EISGMNTLLC APIQTQMQQK EFSITDCNHE RKHANDQTVI FSDENQMDLT ASHTVMITKG LSDCTKNENS TKIDTTSFLE NLKHHAANSR IKKDLACSTV SLSQNIFSEK INSDNFIKRL KTGKHISSST ELDKENAEIP VYSKDSNSAS STYQMHASLG VDENSSNRTR IFREQDDGMN LTQCHTACIK TWIPPSTEAK IGEFKGDKTI YGNECMELTT NYTIQVLSSE NNLSERETQT QNGMNVTTVD GATAPAPEKK TALKDKLNAA FQGSFPNPEN KIHIIKCHPI ESETHTVTQI SSQSASTLAV TSKSICSSPA IEGYKTIFHS SSNDAMELTK CLSAMEEEKK LLKADDKYSK ICTNPDAGPL REKTIYLEED SMDITKSHTV AIDNKIFKHD QENIKKEIIA IPIFEKEMVL RNLMPMSKDE KRDVNYISVP QVSKESLQRS QTNTLSVSLT DKKMEFLADE DMDLTKSHTT KLSQVIPTTF DLASKNVTKS YSHSKSPLNE WESLDKQVVL GQHSKLPLPQ RKDRDDPDCS HHKIMYSEEL QTMDLTKSHT IVIGFGPSEV QEHSKINLEH KNSQLTAESI QTAVNVPAAN SRVVTTNDMD MLKDRSTHKP ELLKEKQNIK IYGRKSIGRL KIDKTILFSE GNEGDMDITK SCTVKINHRS LLDKHDSHLV SLAGTSKTIL HARGQVEMEI NRSHTTPLEC KIISPSDITP GDLDKTMMSI DDHEELDMTK SHTVFIDYQA EAKGVLPDRL DFQLSKKESL QKPKVTSLAE EIYISKNSES NHLPAKGSQL TILEEGSNSG LGEETNDAQK PGFLNELLSG KTQRRKSLSL KNKSITFPEN DKSYREIPQS SAVEINNETR LEDRKGFSFV PLAGTSKPVL SAYGPEDMEI SIGQTTASEY KTVPPEEITT IPMDKTVMFV DNFGDLDVTR SHTVFIDCQA KEKVLDEYTN LGIQKTKTLS GSEGDTHIQE ITKNPAAQHK HHMTTVIPSS TVVSDQSSMK IKFHKADRDE EVKGKEVEAN MLKQTKPESC LLNITDGKNV DFTSSYTADV CRSSDKYSSL PNISSSDNSG GNTMSLCDKN KEKAYNCQVP NEFTYAAILP STYHMDSKKL SVFPPCPSKE VTQTESAIAL LKDEDPVEEP LGEMATFNSK HVSLNLAKDQ TEAFVDVSVA SQPHLSAQQS PSTQKGQDVA RRDEGILAKA GKKALPFLLE NVAASTWENE SKIPTNVEHF AVTYEKELSI SIQTDKCNTN VQSPSNSALT TQVIQTHANA EGALDFLVPS TVSCFSSTKP SLSNLNRKTE EVLDFQTVNL LPPAEQLLEE GSQAHSMSIV QATEIYRLGS RNDRDEESKT FCNEAETTSV PLKTAVKDKT RRCSLGIFLP KLPSKRSCSI TGVDDLEQIL ADAADLTQLE TQPVCSKDPG IGSVAAKLNL SPSQFINEEN LPVYPGEILS SDSVSLDIEE SVLIDTSQRE SLPSENKTEN CRAQKRTRVE ENDVTNEKKI RTHDSAQDQE VSCLEPKNVL EF
Research Areas
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Background

Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Directly links spindle checkpoint proteins BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (By similarity).

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$ 80.00
Cat# BP19227b
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