IL5RA Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q01344 |
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Clone Names | 100311184 |
Gene ID | 3568 |
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Other Names | Interleukin-5 receptor subunit alpha, IL-5 receptor subunit alpha, IL-5R subunit alpha, IL-5R-alpha, IL-5RA, CDw125, CD125, IL5RA, IL5R |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | IL5RA |
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Synonyms | IL5R |
Function | Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:9378992). Acts by forming an heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5 (PubMed:1495999, PubMed:22528658). In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). |
Cellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Location | Expressed on eosinophils and basophils. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is an interleukin 5specific subunit of a heterodimeric cytokine receptor. The receptoris comprised of a ligand specific alpha subunit and a signaltransducing beta subunit shared by the receptors for interleukin 3(IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5(IL5). The binding of this protein to IL5 depends on the betasubunit. The beta subunit is activated by the ligand binding, andis required for the biological activities of IL5. This protein hasbeen found to interact with syndecan binding protein (syntenin),which is required for IL5 mediated activation of the transcriptionfactor SOX4. Six alternatively spliced transcript variants encodingthree distinct isoforms have been reported.
References
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Beckers, M.M., et al. Eur. J. Intern. Med. 21(4):289-292(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Wang, Y., et al. Diabet. Med. 27(4):376-383(2010)
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