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BCCIP Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9P287
Clone Names 5082453
Peptide ID 5082453
Additional Information
Gene ID 56647
Other Names BRCA2 and CDKN1A-interacting protein, P21- and CDK-associated protein 1, Protein TOK-1, BCCIP, TOK1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1923b was selected from the C-term region of human BCCIP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms TOK1
Function May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
Cellular Location Nucleus Note=Colocalizes with BRCA2 in discrete nuclear foci
Tissue Location Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen
Research Areas
Citations (0)

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BCCIP was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21.


Lu, H., et al., Mol. Cell. Biol. 25(5):1949-1957 (2005).Meng, X., et al., Cell Cycle 3(3):343-348 (2004).Robson, M., et al., J. Med. Genet. 39(2):126-128 (2002).Armakolas, A., et al., Hum. Mutat. 19(1):81-82 (2002).Liu, J., et al., Oncogene 20(3):336-345 (2001).

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$ 80.00
Cat# BP1923b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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