|Other Names||Synapsin-1, Brain protein 41, Synapsin I, SYN1|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.|
|Cellular Location||Cell junction, synapse. Golgi apparatus|
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This gene is a member of the synapsin gene family.Synapsins encode neuronal phosphoproteins which associate with thecytoplasmic surface of synaptic vesicles. Family members arecharacterized by common protein domains, and they are implicated insynaptogenesis and the modulation of neurotransmitter release,suggesting a potential role in several neuropsychiatric diseases.This member of the synapsin family plays a role in regulation ofaxonogenesis and synaptogenesis. The protein encoded serves as asubstrate for several different protein kinases and phosphorylationmay function in the regulation of this protein in the nerveterminal. Mutations in this gene may be associated with X-linkeddisorders with primary neuronal degeneration such as Rett syndrome.Alternatively spliced transcript variants encoding differentisoforms have been identified.
Smith, A.J., et al. J. Acquir. Immune Defic. Syndr. 55(3):306-315(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Wang, J.L., et al. J. Neurosci. Res. 87(10):2255-2263(2009)
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