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bcl-2 Antibody (Center S70) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P10415
Clone Names 120106032
Peptide ID 120106032
Additional Information
Gene ID 596
Other Names Apoptosis regulator Bcl-2, BCL2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL2
Function Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Cellular Location Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein
Tissue Location Expressed in a variety of tissues.
Research Areas
Citations (0)

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This gene encodes an integral outer mitochondrial membraneprotein that blocks the apoptotic death of some cells such aslymphocytes. Constitutive expression of BCL2, such as in the caseof translocation of BCL2 to Ig heavy chain locus, is thought to bethe cause of follicular lymphoma. Two transcript variants, producedby alternate splicing, differ in their C-terminal ends. [providedby RefSeq].


Feng, H., et al. Cancer Cell 18(4):353-366(2010)Azad, N., et al. Ann. N. Y. Acad. Sci. 1203, 1-6 (2010) :Dubikov, A.I., et al. Scand. J. Rheumatol. 39(5):368-372(2010)Yu, B., et al. J. Exp. Clin. Cancer Res. 29, 107 (2010) :Trisciuoglio, D., et al. PLoS ONE 5 (7), E11772 (2010) :

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$ 80.00
Cat# BP19252c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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