|Other Names||Forkhead box protein N3, Checkpoint suppressor 1, FOXN3, C14orf116, CHES1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).|
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This gene is a member of the forkhead/winged helixtranscription factor family. Checkpoints are eukaryotic DNAdamage-inducible cell cycle arrests at G1 and G2. Checkpointsuppressor 1 suppresses multiple yeast checkpoint mutationsincluding mec1, rad9, rad53 and dun1 by activating aMEC1-independent checkpoint pathway. Alternative splicing isobserved at the locus, resulting in distinct isoforms. [provided byRefSeq].
Samaan, G., et al. Biochem. Biophys. Res. Commun. 400(1):60-65(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Markowski, J., et al. Eur Arch Otorhinolaryngol 266(10):1501-1507(2009)Schlade-Bartusiak, K., et al. Am. J. Med. Genet. A 146A (1), 117-123 (2008) :
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