NOC2L Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y3T9 |
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Clone Names | 5082952 |
Gene ID | 26155 |
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Other Names | Nucleolar complex protein 2 homolog, Protein NOC2 homolog, NOC2-like protein, Novel INHAT repressor, NOC2L, NIR |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1925a was selected from the Center region of human NOC2L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NOC2L |
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Synonyms | NIR |
Function | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. |
Cellular Location | Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D Predominantly detected in the nucleoli in non-mitotic cells Predominantly detected in nucleoplasma in cells undergoing mitosis |
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Provided below are standard protocols that you may find useful for product applications.
Background
NOC2L is a novel INHAT (inhibitor of histone acetyltransferase). Upon recruitment by p53, this protein represses transcription of both p53-dependent reporters and endogenous target genes.
References
Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).
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