|Other Names||Nucleolar complex protein 2 homolog, Protein NOC2 homolog, NOC2-like protein, Novel INHAT repressor, NOC2L, NIR|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1925a was selected from the Center region of human NOC2L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.|
|Cellular Location||Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin- D. Predominantly detected in the nucleoli in non-mitotic cells Predominantly detected in nucleoplasma in cells undergoing mitosis|
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Provided below are standard protocols that you may find useful for product applications.
NOC2L is a novel INHAT (inhibitor of histone acetyltransferase). Upon recruitment by p53, this protein represses transcription of both p53-dependent reporters and endogenous target genes.
Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).
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