|Other Names||Neutrophil defensin 3, Defensin, alpha 3, HNP-3, HP-3, HP3, HP 3-56, Neutrophil defensin 2, HNP-2, HP-2, HP2, DEFA3, DEF3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.|
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Defensins are a family of microbicidal and cytotoxicpeptides thought to be involved in host defense. They are abundantin the granules of neutrophils and also found in the epithelia ofmucosal surfaces such as those of the intestine, respiratory tract,urinary tract, and vagina. Members of the defensin family arehighly similar in protein sequence and distinguished by a conservedcysteine motif. The protein encoded by this gene, defensin, alpha3, is found in the microbicidal granules of neutrophils and likelyplays a role in phagocyte-mediated host defense. Several alphadefensin genes are clustered on chromosome 8. This gene differsfrom defensin, alpha 1 by only one amino acid. This gene and thegene encoding defensin, alpha 1 are both subject to copy numbervariation.
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Chen, Q., et al. Anesthesiology 112(6):1428-1434(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Paslakis, G., et al. Nephron Exp. Nephrol. 115 (4), E96-E100 (2010) :Rodriguez-Garcia, M., et al. PLoS ONE 5 (2), E9436 (2010) :
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