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DEFA3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P59666 |
|---|---|
| Clone Names | 100623009 |
| Gene ID | 1668 |
|---|---|
| Other Names | Neutrophil defensin 3, Defensin, alpha 3, HNP-3, HP-3, HP3, HP 3-56, Neutrophil defensin 2, HNP-2, HP-2, HP2, DEFA3, DEF3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DEFA3 |
|---|---|
| Synonyms | DEF3 |
| Function | Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses (PubMed:15616305, PubMed:15772169, PubMed:17142766). Possesses the ability to neutralize bacterial toxins such as B. anthracis lethal factor, Clostridium difficile cytotoxin B as well as leukocidin produced by Staphylococcus aureus (PubMed:15772169, PubMed:18435932, PubMed:25963798). Blocks also herpes simplex virus infection by interacting with envelope glycoprotein B and thus preventing its binding to heparan sulfate, the receptor for attachment (PubMed:17142766). |
| Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Defensins are a family of microbicidal and cytotoxicpeptides thought to be involved in host defense. They are abundantin the granules of neutrophils and also found in the epithelia ofmucosal surfaces such as those of the intestine, respiratory tract,urinary tract, and vagina. Members of the defensin family arehighly similar in protein sequence and distinguished by a conservedcysteine motif. The protein encoded by this gene, defensin, alpha3, is found in the microbicidal granules of neutrophils and likelyplays a role in phagocyte-mediated host defense. Several alphadefensin genes are clustered on chromosome 8. This gene differsfrom defensin, alpha 1 by only one amino acid. This gene and thegene encoding defensin, alpha 1 are both subject to copy numbervariation.
References
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Chen, Q., et al. Anesthesiology 112(6):1428-1434(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Paslakis, G., et al. Nephron Exp. Nephrol. 115 (4), E96-E100 (2010) :Rodriguez-Garcia, M., et al. PLoS ONE 5 (2), E9436 (2010) :
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