|Other Names||Kunitz-type protease inhibitor 2, Hepatocyte growth factor activator inhibitor type 2, HAI-2, Placental bikunin, SPINT2, HAI2, KOP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea|
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This gene encodes a transmembrane protein with twoextracellular Kunitz domains that inhibits a variety of serineproteases. The protein inhibits HGF activator which prevents theformation of active hepatocyte growth factor. This gene is aputative tumor suppressor, and mutations in this gene result incongenital sodium diarrhea. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Dong, W., et al. Int. J. Cancer 127(7):1526-1534(2010)Bergum, C., et al. Prostate 70(13):1422-1428(2010)Sivagnanam, M., et al. Clin. Dysmorphol. 19 (1), 48 (2010) :Yamauchi, M., et al. Biol. Chem. 383(12):1953-1957(2002)Itoh, H., et al. Eur. J. Biochem. 267(11):3351-3359(2000)
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