TMEM41B Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q5BJD5 |
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Clone Names | 100416281 |
Gene ID | 440026 |
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Other Names | Transmembrane protein 41B, TMEM41B, KIAA0033 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TMEM41B {ECO:0000303|PubMed:30352685, ECO:0000312|HGNC:HGNC:28948} |
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Function | Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (PubMed:34015269, PubMed:33929485, PubMed:33850023). Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine (PubMed:34015269, PubMed:33929485, PubMed:33850023). Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly (PubMed:30093494, PubMed:30126924, PubMed:30933966, PubMed:34015269, PubMed:33929485, PubMed:34043740, PubMed:33850023). In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (PubMed:33850023). Required for normal motor neuron development (By similarity). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Endomembrane system Note=Localized to specific membrane structures termed mitochondria- associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TMEM41B belongs to the TMEM41 family and it has two isoforms.
References
Kimura, K., et al. Genome Res. 16(1):55-65(2006)Hillier, L.D., et al. Genome Res. 6(9):807-828(1996)
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