|Other Names||Mitogen-activated protein kinase kinase kinase 12, Dual leucine zipper bearing kinase, DLK, Leucine-zipper protein kinase, ZPK, MAPK-upstream kinase, MUK, Mixed lineage kinase, MAP3K12, ZPK|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein|
|Tissue Location||Highly expressed in brain and kidney.|
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This gene encodes a member of the serine/threonine proteinkinase family. This kinase contains a leucine-zipper domain and ispredominately expressed in neuronal cells. The phosphorylationstate of this kinase in synaptic terminals was shown to beregulated by membrane depolarization via calcineurin. This kinaseforms heterodimers with leucine zipper containing transcriptionfactors, such as cAMP responsive element binding protein (CREB) andMYC, and thus may play a regulatory role in PKA or retinoic acidinduced neuronal differentiation. Alternatively spliced transcriptvariants encoding different proteins have been described.[providedby RefSeq].
Clague, J., et al. Mol. Carcinog. 49(2):183-189(2010)Robitaille, H., et al. J. Invest. Dermatol. 130(1):74-85(2010)Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009) :Daviau, A., et al. Cell. Signal. 21(4):577-587(2009)Mukhopadhyay, R., et al. Mol. Cell 32(3):371-382(2008)
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