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IsocitRe dehydrogenase (IDH3) Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P50213
Clone Names 5082954
Additional Information
Gene ID 3419
Other Names Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitric dehydrogenase subunit alpha, NAD(+)-specific ICDH subunit alpha, IDH3A
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1927a was selected from the C-term region of human Isocitrate dehydrogenase. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IDH3A (HGNC:5384)
Function Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
Cellular Location Mitochondrion.
Research Areas
Citations (0)
citation

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Background

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein described here is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase.

References

Soundar, S., et al., J. Biol. Chem. 278(52):52146-52153 (2003).Weiss, C., et al., Biochemistry 39(7):1807-1816 (2000).Kim, Y.O., et al., J. Biol. Chem. 274(52):36866-36875 (1999).Huh, T.L., et al., Genomics 32(2):295-296 (1996).Kim, Y.O., et al., Biochem. J. 308 (PT 1), 63-68 (1995) (): ().

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$ 277.78
Cat# BP1927a
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