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RNF31 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96EP0
Clone Names 100528283
Peptide ID 100528283
Additional Information
Gene ID 55072
Other Names E3 ubiquitin-protein ligase RNF31, 632-, HOIL-1-interacting protein, HOIP, RING finger protein 31, Zinc in-between-RING-finger ubiquitin-associated domain protein, RNF31, ZIBRA
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF31
Synonyms ZIBRA
Function E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF- induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.
Cellular Location Cytoplasm.
Tissue Location Expressed in both normal and transformed breast epithelial cell lines.
Research Areas
Citations (0)

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The protein encoded by this gene contains a RING finger, amotif present in a variety of functionally distinct proteins andknown to be involved in protein-DNA and protein-proteininteractions.


Silva, L.K., et al. Eur. J. Hum. Genet. (2010) In press :Ehrlund, A., et al. Mol. Cell. Biol. 29(8):2230-2242(2009)Tokunaga, F., et al. Nat. Cell Biol. 11(2):123-132(2009)Kirisako, T., et al. EMBO J. 25(20):4877-4887(2006)Lim, J., et al. Cell 125(4):801-814(2006)

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$ 80.00
Cat# BP19285b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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