|Other Names||E3 ubiquitin-protein ligase RNF31, 632-, HOIL-1-interacting protein, HOIP, RING finger protein 31, Zinc in-between-RING-finger ubiquitin-associated domain protein, RNF31, ZIBRA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF- induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.|
|Tissue Location||Expressed in both normal and transformed breast epithelial cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene contains a RING finger, amotif present in a variety of functionally distinct proteins andknown to be involved in protein-DNA and protein-proteininteractions.
Silva, L.K., et al. Eur. J. Hum. Genet. (2010) In press :Ehrlund, A., et al. Mol. Cell. Biol. 29(8):2230-2242(2009)Tokunaga, F., et al. Nat. Cell Biol. 11(2):123-132(2009)Kirisako, T., et al. EMBO J. 25(20):4877-4887(2006)Lim, J., et al. Cell 125(4):801-814(2006)
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