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FCGRT Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P55899 |
|---|---|
| Clone Names | 100617276 |
| Gene ID | 2217 |
|---|---|
| Other Names | IgG receptor FcRn large subunit p51, FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, FCGRT, FCRN |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FCGRT |
|---|---|
| Synonyms | FCRN |
| Function | Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7964511, PubMed:10933786). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P13599}; Single-pass type I membrane protein. Endosome membrane |
| Tissue Location | Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a receptor that binds the Fc region ofmonomeric immunoglobulin G. The encoded protein transfersimmunoglobulin G antibodies from mother to fetus across theplacenta. This protein also binds immunoglobulin G to protect theantibody from degradation. Alternative splicing results in multipletranscript variants.
References
Mezo, A.R., et al. J. Biol. Chem. 285(36):27694-27701(2010)Freiberger, T., et al. Clin. Immunol. 136(3):419-425(2010)Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Freiberger, T., et al. J. Reprod. Immunol. 85(2):193-197(2010)Mikulska, J.E., et al. Eur. J. Immunogenet. 27(4):231-240(2000)
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