|Other Names||IgG receptor FcRn large subunit p51, FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, FCGRT, FCRN|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a receptor that binds the Fc region ofmonomeric immunoglobulin G. The encoded protein transfersimmunoglobulin G antibodies from mother to fetus across theplacenta. This protein also binds immunoglobulin G to protect theantibody from degradation. Alternative splicing results in multipletranscript variants.
Mezo, A.R., et al. J. Biol. Chem. 285(36):27694-27701(2010)Freiberger, T., et al. Clin. Immunol. 136(3):419-425(2010)Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Freiberger, T., et al. J. Reprod. Immunol. 85(2):193-197(2010)Mikulska, J.E., et al. Eur. J. Immunogenet. 27(4):231-240(2000)
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