|Other Names||Aquaporin-3, AQP-3, Aquaglyceroporin-3, AQP3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).|
|Cellular Location||Basolateral cell membrane; Multi-pass membrane protein. Note=In collecting ducts of kidney|
|Tissue Location||Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level|
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Provided below are standard protocols that you may find useful for product applications.
Aquaporin 3 is a water channel protein. Aquaporins are afamily of small integral membrane proteins related to the majorintrinsic protein (MIP or AQP0). Aquaporin 3 is localized at thebasal lateral membranes of collecting duct cells in the kidney. Inaddition to its water channel function, aquaporin 3 has been foundto facilitate the transport of nonionic small solutes such as ureaand glycerol, but to a smaller degree. It has been suggested thatwater channels can be functionally heterogeneous and possess waterand solute permeation mechanisms.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kim, N.H., et al. J. Invest. Dermatol. 130(9):2231-2239(2010)Ji, C., et al. Int. J. Mol. Med. 26(2):257-263(2010)Melis, M., et al. Dis. Colon Rectum 53(6):936-943(2010)Shen, L., et al. Biomed. Pharmacother. 64(5):313-318(2010)
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