|Other Names||Rhophilin-2, 76 kDa RhoB effector protein, GTP-Rho-binding protein 2, p76RBE, RHPN2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.|
|Cellular Location||Cytoplasm, perinuclear region|
|Tissue Location||Widely expressed. Highly expressed in prostate, trachea, stomach, colon, thyroid and pancreas. Expressed at lower level in brain, spinal cord, kidney, placenta and liver|
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This gene encodes a member of the rhophilin family ofRas-homologous (Rho)-GTPase binding proteins. The encoded proteinbinds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may beinvolved in the organization of the actin cytoskeleton. [providedby RefSeq].
Abuli, A., et al. Gastroenterology 139(3):788-796(2010)von Holst, S., et al. Br. J. Cancer 103(4):575-580(2010)Kupfer, S.S., et al. Gastroenterology (2010) In press :Xiong, F., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1855-1861(2010)Hawken, S.J., et al. Hum. Genet. 128(1):89-101(2010)
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