|Other Names||Ectonucleoside triphosphate diphosphohydrolase 5, NTPDase 5, CD39 antigen-like 4, ER-UDPase, Guanosine-diphosphatase ENTPD5, GDPase ENTPD5, Nucleoside diphosphatase, Uridine-diphosphatase ENTPD5, UDPase ENTPD5, ENTPD5, CD39L4, PCPH|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.|
|Cellular Location||Endoplasmic reticulum. Secreted|
|Tissue Location||Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is similar to E-typenucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such asCD39, mediate catabolism of extracellular nucleotides. ENTPD5contains 4 apyrase-conserved regions which is characteristic ofNTPases.
Fransen, K., et al. Hum. Mol. Genet. 19(17):3482-3488(2010)Villar, J., et al. Cancer Res. 69(1):102-110(2009)Villar, J., et al. Cancer Res. 67(22):10859-10868(2007)Regadera, J., et al. Int. J. Oncol. 28(3):595-604(2006)Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)
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