|Other Names||Signal-regulatory protein beta-1, SIRP-beta-1, CD172 antigen-like family member B, CD172b, SIRPB1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Detected in monocytes and dendritic cells.|
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The protein encoded by this gene is a member of thesignal-regulatory-protein (SIRP) family, and also belongs to theimmunoglobulin superfamily. SIRP family members are receptor-typetransmembrane glycoproteins known to be involved in the negativeregulation of receptor tyrosine kinase-coupled signaling processes.This protein was found to interact with TYROBP/DAP12, a proteinbearing immunoreceptor tyrosine-based activation motifs. Thisprotein was also reported to participate in the recruitment oftyrosine kinase SYK. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Gaikwad, S., et al. Am. J. Pathol. 175(6):2528-2539(2009)Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)Martins-de-Souza, D., et al. J Neural Transm 116(3):275-289(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)van den Berg, T.K., et al. J. Immunol. 175(12):7788-7789(2005)
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