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SIRPB1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O00241 |
|---|---|
| Clone Names | 110901137 |
| Gene ID | 10326 |
|---|---|
| Other Names | Signal-regulatory protein beta-1, SIRP-beta-1, CD172 antigen-like family member B, CD172b, SIRPB1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SIRPB1 |
|---|---|
| Function | Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP (PubMed:10604985). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Detected in monocytes and dendritic cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of thesignal-regulatory-protein (SIRP) family, and also belongs to theimmunoglobulin superfamily. SIRP family members are receptor-typetransmembrane glycoproteins known to be involved in the negativeregulation of receptor tyrosine kinase-coupled signaling processes.This protein was found to interact with TYROBP/DAP12, a proteinbearing immunoreceptor tyrosine-based activation motifs. Thisprotein was also reported to participate in the recruitment oftyrosine kinase SYK. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
References
Gaikwad, S., et al. Am. J. Pathol. 175(6):2528-2539(2009)Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)Martins-de-Souza, D., et al. J Neural Transm 116(3):275-289(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)van den Berg, T.K., et al. J. Immunol. 175(12):7788-7789(2005)
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