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Mouse Derl2 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8BNI4
Clone Names 110919069
Peptide ID 110919069
Additional Information
Gene ID 116891
Other Names Derlin-2, Degradation in endoplasmic reticulum protein 2, Der1-like protein 2, F-LANa, Derl2, Der2, Flana
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Derl2
Synonyms Der2, Flana
Function Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate (By similarity).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Widely expressed, with lowest levels in brain and heart.
Research Areas
Citations (0)

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Background

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate (By similarity).

References

Schaheen, B., et al. J. Cell. Sci. 122 (PT 13), 2228-2239 (2009) :Oda, Y., et al. J. Cell Biol. 172(3):383-393(2006)Lilley, B.N., et al. Proc. Natl. Acad. Sci. U.S.A. 102(40):14296-14301(2005)Kaput, J., et al. Physiol. Genomics 18(3):316-324(2004)Lilley, B.N., et al. Nature 429(6994):834-840(2004)

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$ 80.00
Cat# BP19315b
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