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BAZ1B Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UIG0
Clone Names 100427312
Peptide ID 100427312
Additional Information
Gene ID 9031
Other Names Tyrosine-protein kinase BAZ1B, Bromodomain adjacent to zinc finger domain protein 1B, Williams syndrome transcription factor, Williams-Beuren syndrome chromosomal region 10 protein, Williams-Beuren syndrome chromosomal region 9 protein, hWALp2, BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAZ1B
Synonyms WBSC10, WBSCR10, WBSCR9, WSTF
Function Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00063, ECO:0000255|PROSITE-ProRule:PRU00475, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136} Note=Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA
Tissue Location Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary
Research Areas
Citations (0)

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This gene encodes a member of the bromodomain proteinfamily. The bromodomain is a structural motif characteristic ofproteins involved in chromatin-dependent regulation oftranscription. This gene is deleted in Williams-Beuren syndrome, adevelopmental disorder caused by deletion of multiple genes at7q11.23.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Johansen, C.T., et al. Nat. Genet. 42(8):684-687(2010)Chidambaram, M., et al. Metab. Clin. Exp. (2010) In press :Oya, H., et al. J. Biol. Chem. 284(47):32472-32482(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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$ 80.00
Cat# BP19326a
(40 western blots)
Availability: In Stock
Bulk Size
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