|Other Names||Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, PP2A B subunit isoform B'-delta, PP2A B subunit isoform B56-delta, PP2A B subunit isoform PR61-delta, PP2A B subunit isoform R5-delta, PPP2R5D|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.|
|Cellular Location||Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis|
|Tissue Location||Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain|
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The product of this gene belongs to the phosphatase 2Aregulatory subunit B family. Protein phosphatase 2A is one of thefour major Ser/Thr phosphatases, and it is implicated in thenegative control of cell growth and division. It consists of acommon heteromeric core enzyme, which is composed of a catalyticsubunit and a constant regulatory subunit, that associates with avariety of regulatory subunits. The B regulatory subunit mightmodulate substrate selectivity and catalytic activity. This geneencodes a delta isoform of the regulatory subunit B56 subfamily.Alternatively spliced transcript variants encoding differentisoforms have been identified.
Yu, U.Y., et al. BMB Rep 43(4):263-267(2010)Reece, K.M., et al. Biochem. Biophys. Res. Commun. 386(4):582-587(2009)Forester, C.M., et al. Proc. Natl. Acad. Sci. U.S.A. 104(50):19867-19872(2007)Sablina, A.A., et al. Cell 129(5):969-982(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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