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SF3A1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q15459
Clone Names 5082959
Additional Information
Gene ID 10291
Other Names Splicing factor 3A subunit 1, SF3a120, Spliceosome-associated protein 114, SAP 114, SF3A1, SAP114
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1932a was selected from the Center region of human SF3A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SF3A1
Synonyms SAP114
Function Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
Cellular Location Nucleus.
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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SF3A1 is subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family, named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs.


Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135 (2004).Nesic, D., et al., Mol. Cell. Biol. 21(19):6406-6417 (2001).Das, R., et al., Mol. Cell 5(5):779-787 (2000).Ajuh, P., et al., EMBO J. 19(23):6569-6581 (2000).Kramer, A., et al., J. Cell Biol. 145(7):1355-1368 (1999).

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$ 80.00
Cat# BP1932a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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