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TRIM29 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q14134 |
|---|---|
| Clone Names | 100517065 |
| Gene ID | 23650 |
|---|---|
| Other Names | Tripartite motif-containing protein 29, Ataxia telangiectasia group D-associated protein, TRIM29, ATDC |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TRIM29 |
|---|---|
| Synonyms | ATDC |
| Function | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. |
| Cellular Location | Cytoplasm. Lysosome. Note=Colocalizes with intermediate filaments |
| Tissue Location | Expressed in placenta, prostate and thymus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the TRIMprotein family. It has multiple zinc finger motifs and a leucinezipper motif. It has been proposed to form homo- or heterodimerswhich are involved in nucleic acid binding. Thus, it may act as atranscriptional regulatory factor involved in carcinogenesis and/ordifferentiation. It may also function in the suppression ofradiosensitivity since it is associated with ataxia telangiectasiaphenotype.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Yuan, Z., et al. Mol. Cell. Biol. 30(12):3004-3015(2010)Chattopadhyay, I., et al. Mutat. Res. 696(2):130-138(2010)Bertrand-Vallery, V., et al. PLoS ONE 5 (5), E10462 (2010) :Ring, B.Z., et al. Mod. Pathol. 22(8):1032-1043(2009)
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