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APG4B Antibody (Center G254) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9Y4P1
Clone Names 70226107
Peptide ID 70226107
Additional Information
Gene ID 23192
Other Names Cysteine protease ATG4B, 3422-, AUT-like 1 cysteine endopeptidase, Autophagin-1, Autophagy-related cysteine endopeptidase 1, Autophagy-related protein 4 homolog B, hAPG4B, ATG4B, APG4B, AUTL1, KIAA0943
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATG4B
Synonyms APG4B, AUTL1, KIAA0943
Function Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C- terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Cellular Location Cytoplasm.
Tissue Location Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas
Research Areas
Citations (0)

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Autophagy is the process by which endogenous proteins anddamaged organelles are destroyed intracellularly. Autophagy ispostulated to be essential for cell homeostasis and cell remodelingduring differentiation, metamorphosis, non-apoptotic cell death,and aging. Reduced levels of autophagy have been described in somemalignant tumors, and a role for autophagy in controlling theunregulated cell growth linked to cancer has been proposed. Thisgene encodes a member of the autophagin protein family. The encodedprotein is also designated as a member of the C-54 family ofcysteine proteases. Alternate transcriptional splice variants,encoding different isoforms, have been characterized. [provided byRefSeq].


Satoo, K., et al. EMBO J. 28(9):1341-1350(2009)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)

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$ 80.00
Cat# BP19349c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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