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Importin beta-2 (TNPO1) Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q92973
Clone Names 50908307
Peptide ID 50908307
Additional Information
Gene ID 3842
Other Names Transportin-1, Importin beta-2, Karyopherin beta-2, M9 region interaction protein, MIP, TNPO1, KPNB2, MIP1, TRN
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1934a was selected from the N-term region of human TNPO1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNPO1
Synonyms KPNB2, MIP1, TRN
Function Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9- containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner.
Cellular Location Cytoplasm. Nucleus.
Research Areas
Citations (0)

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TNPO1 comprises the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins.


Fineberg, K., et al., Biochemistry 42(9):2625-2633 (2003).Nelson, L.M., et al., Virology 306(1):162-169 (2003).Le Roux, L.G., et al., J. Virol. 77(4):2330-2337 (2003).Limon, A., et al., J. Virol. 76(21):10598-10607 (2002).Dvorin, J.D., et al., J. Virol. 76(23):12087-12096 (2002).

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$ 80.00
Cat# BP1934a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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