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Cellular Apoptosis Susceptibility Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P55060
Clone Names 50908309
Peptide ID 50908309
Additional Information
Gene ID 1434
Other Names Exportin-2, Exp2, Cellular apoptosis susceptibility protein, Chromosome segregation 1-like protein, Importin-alpha re-exporter, CSE1L, CAS, XPO2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1935b was selected from the C-term region of human CSE1L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CSE1L
Synonyms CAS, XPO2
Function Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm
Tissue Location Highly expressed in proliferating cells.
Research Areas
Citations (0)

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Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, CSE1L may play a role both in apoptosis and in cell proliferation.


Goldberg, G.S., et al., J. Biol. Chem. 278(47):46533-46540 (2003).Behrens, P., et al., Apoptosis 8(1):39-44 (2003).Jiang, M.C., et al., Biochem. Biophys. Res. Commun. 294(4):900-905 (2002).Wellmann, A., et al., Int. J. Mol. Med. 7(5):489-494 (2001).Brinkmann, U., et al., Genomics 58(1):41-49 (1999).

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$ 80.00
Cat# BP1935b
(40 western blots)
Availability: In Stock
Bulk Size
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