|Other Names||Protein SMG5, EST1-like protein B, LPTS-RP1, LPTS-interacting protein, SMG-5 homolog, hSMG-5, SMG5, EST1B, KIAA1089|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm Detected in cytoplasmic mRNA decay bodies|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
SMG5 is involved in nonsense-mediated mRNA decay (Ohnishiet al., 2003 [PubMed 14636577]).
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)Glavan, F., et al. EMBO J. 25(21):5117-5125(2006)Lee, H., et al. Mol. Cell. Biol. 26(14):5259-5269(2006)Azzalin, C.M., et al. Curr. Biol. 16(4):433-439(2006)Unterholzner, L., et al. Mol. Cell 16(4):587-596(2004)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.