|Other Names||DNA repair protein XRCC2, X-ray repair cross-complementing protein 2, XRCC2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome|
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This gene encodes a member of the RecA/Rad51-relatedprotein family that participates in homologous recombination tomaintain chromosome stability and repair DNA damage. This gene isinvolved in the repair of DNA double-strand breaks by homologousrecombination and it functionally complements Chinese hamster irs1,a repair-deficient mutant that exhibits hypersensitivity to anumber of different DNA-damaging agents.
Liu, Y., et al. Carcinogenesis 31(10):1762-1769(2010)Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :Lipkin, S.M., et al. Cancer Prev Res (Phila) 3(5):597-603(2010)
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