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AKTIP Antibody(C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H8T0 |
|---|---|
| Clone Names | 110826012 |
| Gene ID | 64400 |
|---|---|
| Other Names | AKT-interacting protein, Ft1, Fused toes protein homolog, AKTIP, FTS |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | AKTIP (HGNC:16710) |
|---|---|
| Function | Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). |
| Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
The mouse homolog of this gene produces fused toes andthymic hyperplasia in heterozygous mutant animals while homozygousmutants die in early development. This gene may play a role inapoptosis as these morphological abnormalities are caused byaltered patterns of programmed cell death. The protein encoded bythis gene is similar to the ubiquitin ligase domain of otherubiquitin-conjugating enzymes but lacks the conserved cysteineresidue that enables those enzymes to conjugate ubiquitin to thetarget protein. This protein interacts directly withserine/threonine kinase protein kinase B (PKB)/Akt and modulatesPKB activity by enhancing the phosphorylation of PKB's regulatorysites. Alternative splicing results in two transcript variantsencoding the same protein.
References
Notaridou, M., et al. Int. J. Cancer (2010) In press :Quaye, L., et al. Hum. Mol. Genet. 18(10):1869-1878(2009)Xu, L., et al. Mol. Biol. Cell 19(12):5059-5071(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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