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AKTIP Antibody(C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9H8T0
Clone Names 110826012
Peptide ID 110826012
Additional Information
Gene ID 64400
Other Names AKT-interacting protein, Ft1, Fused toes protein homolog, AKTIP, FTS
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FTS
Function Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein
Research Areas
Citations (0)

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The mouse homolog of this gene produces fused toes andthymic hyperplasia in heterozygous mutant animals while homozygousmutants die in early development. This gene may play a role inapoptosis as these morphological abnormalities are caused byaltered patterns of programmed cell death. The protein encoded bythis gene is similar to the ubiquitin ligase domain of otherubiquitin-conjugating enzymes but lacks the conserved cysteineresidue that enables those enzymes to conjugate ubiquitin to thetarget protein. This protein interacts directly withserine/threonine kinase protein kinase B (PKB)/Akt and modulatesPKB activity by enhancing the phosphorylation of PKB's regulatorysites. Alternative splicing results in two transcript variantsencoding the same protein.


Notaridou, M., et al. Int. J. Cancer (2010) In press :Quaye, L., et al. Hum. Mol. Genet. 18(10):1869-1878(2009)Xu, L., et al. Mol. Biol. Cell 19(12):5059-5071(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

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$ 80.00
Cat# BP19369b
(40 western blots)
Availability: In Stock
Bulk Size
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