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ACO2 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q99798
Clone Names 50908312
Peptide ID 50908312
Additional Information
Gene ID 50
Other Names Aconitate hydratase, mitochondrial, Aconitase, Citrate hydro-lyase, ACO2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1936a was selected from the N-term region of human Aconitase. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACO2
Function Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Cellular Location Mitochondrion.
Research Areas
Citations (0)

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Background

ACO2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.

References

Juang, H.H., Mol. Genet. Metab. 81(3):244-252 (2004).Bota, D.A., et al., Nat. Cell Biol. 4(9):674-680 (2002).Gruer, M.J., et al., Trends Biochem. Sci. 22(1):3-6 (1997).Klausner, R.D., et al., Mol. Biol. Cell 4(1):1-5 (1993).Geurts van Kessel, A.H., et al., Cytogenet. Cell Genet. 28(3):169-172 (1980).

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$ 80.00
Cat# BP1936a
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