|Other Names||Aconitate hydratase, mitochondrial, Aconitase, Citrate hydro-lyase, ACO2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1936c was selected from the Center region of human ACO2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|
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Provided below are standard protocols that you may find useful for product applications.
ACO2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.
Juang, H.H., Mol. Genet. Metab. 81(3):244-252 (2004).Bota, D.A., et al., Nat. Cell Biol. 4(9):674-680 (2002).Gruer, M.J., et al., Trends Biochem. Sci. 22(1):3-6 (1997).Klausner, R.D., et al., Mol. Biol. Cell 4(1):1-5 (1993).Geurts van Kessel, A.H., et al., Cytogenet. Cell Genet. 28(3):169-172 (1980).
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