TMPRSS6 Antibody(N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8IU80 |
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Clone Names | 100427174 |
Gene ID | 164656 |
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Other Names | Transmembrane protease serine 6, 3421-, Matriptase-2, TMPRSS6 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TMPRSS6 |
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Function | Membrane-bound serine protease (PubMed:18976966, PubMed:20518742, PubMed:25156943, PubMed:25588876). Through the cleavage of cell surface HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis (PubMed:25156943, PubMed:18408718, PubMed:18976966). |
Cellular Location | Cell membrane; Single-pass type II membrane protein. Note=The processed, activated two-chains form is released in the extracellular space. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a type IItransmembrane serine proteinase that is found attached to the cellsurface. The encoded protein may be involved in matrix remodelingprocesses in the liver.
References
Altamura, S., et al. Biochem. J. 431(3):363-371(2010)Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)De Falco, L., et al. Hum. Mutat. 31 (5), E1390-E1405 (2010) :Tanaka, T., et al. Blood 115(1):94-96(2010)Lee, P. Acta Haematol. 122 (2-3), 87-96 (2009) :
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