|Other Names||Transmembrane protease serine 6, 3421-, Matriptase-2, TMPRSS6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HFE2, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis.|
|Cellular Location||Cell membrane; Single- pass type II membrane protein. Note=The processed, activated two- chains form is released in the extracellular space|
|Tissue Location||Liver specific..|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a type IItransmembrane serine proteinase that is found attached to the cellsurface. The encoded protein may be involved in matrix remodelingprocesses in the liver.
Altamura, S., et al. Biochem. J. 431(3):363-371(2010)Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)De Falco, L., et al. Hum. Mutat. 31 (5), E1390-E1405 (2010) :Tanaka, T., et al. Blood 115(1):94-96(2010)Lee, P. Acta Haematol. 122 (2-3), 87-96 (2009) :
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