|Other Names||Homeobox protein Hox-A10, Homeobox protein Hox-18, Hoxa10, Hox-18, Hoxa-10|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.|
|Tissue Location||Expressed in the developing limb bud where it is restricted to the mesenchyme along the proximal-distal axis Also found in developing gut and urogenital tract. In adult tissue, both forms found in kidney but only isoform 1 is expressed in skeletal muscle|
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In vertebrates, the genes encoding the class oftranscription factors called homeobox genes are found in clustersnamed A, B, C, and D on four separate chromosomes. Expression ofthese proteins is spatially and temporally regulated duringembryonic development. This gene is part of a cluster on chromosome6 and encodes a DNA-binding transcription factor that may regulategene expression, morphogenesis, and differentiation. Morespecifically, it may function in fertility, embryo viability, andregulation of hematopoietic lineage commitment. Alternativelyspliced transcript variants encoding different isoforms have beendescribed.
Gordon, J.A., et al. Mol. Cell. Biol. 30(14):3531-3541(2010)Das, S.K. Mol. Reprod. Dev. 77(5):387-396(2010)Vinagre, T., et al. Dev. Cell 18(4):655-661(2010)Sadeghi, H., et al. Am. J. Physiol. Endocrinol. Metab. 298 (4), E889-E893 (2010) :Mugford, J.W., et al. Dev. Biol. 333(2):312-323(2009)
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