|Other Names||E3 ubiquitin-protein ligase RNF135, 632-, RIG-I E3 ubiquitin ligase, REUL, RING finger protein 135, Riplet, RNF135|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production.|
|Tissue Location||Expressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue. Also weakly expressed in heart, thymus, liver and lung|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene contains a RING fingerdomain, a motif present in a variety of functionally distinctproteins and known to be involved in protein-protein andprotein-DNA interactions. This gene is located in a chromosomalregion known to be frequently deleted in patients withneurofibromatosis. Alternatively spliced transcript variantsencoding distinct isoforms have been reported. [provided byRefSeq].
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :You, F., et al. Nat. Immunol. 10(12):1300-1308(2009)Visser, R., et al. Am. J. Med. Genet. A 149A (4), 806-808 (2009) :Oshiumi, H., et al. J. Biol. Chem. 284(2):807-817(2009)Gao, D., et al. PLoS ONE 4 (6), E5760 (2009) :
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