|Other Names||SH3 domain-binding protein 4, EH-binding protein 10, Transferrin receptor-trafficking protein, SH3BP4, BOG25, EHB10, TTP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BOG25, EHB10, TTP|
|Function||May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. Alternatively, may acts as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.|
|Cellular Location||Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus|
|Tissue Location||Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein with 3 Asn-Pro-Phe (NPF)motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targetingsignal, and a tyrosine phosphorylation site. This protein isinvolved in cargo-specific control of clathrin-mediatedendocytosis, specifically controlling the internalization of aspecific protein receptor.
Sebastiani, P., et al. Science (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Thalappilly, S., et al. Proteomics 8(15):3071-3081(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Olsen, J.V., et al. Cell 127(3):635-648(2006)
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