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BRMS1 Antibody(N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9HCU9
Clone Names 100525248
Peptide ID 100525248
Additional Information
Gene ID 25855
Other Names Breast cancer metastasis-suppressor 1, BRMS1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BRMS1
Function Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.
Cellular Location Nucleus. Cytoplasm. Note=Predominantly nuclear
Tissue Location Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies
Research Areas
Citations (0)

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This gene reduces the metastatic potential, but not thetumorogenicity, of human breast cancer and melanoma cell lines. Theprotein encoded by this gene localizes primarily to the nucleus andis a component of the mSin3a family of histone deacetylasecomplexes (HDAC). The protein contains two coiled-coil motifs andseveral imperfect leucine zipper motifs. Alternative splicingresults in two transcript variants encoding different isoforms.


Wu, Y., et al. Cancer Lett. 293(1):82-91(2010)Vaidya, K.S., et al. Cancer Lett. 281(1):100-107(2009)Frolova, N., et al. Tumour Biol. 30(3):148-159(2009)Martins-de-Souza, D., et al. BMC Psychiatry 9, 17 (2009) :Cicek, M., et al. Clin. Exp. Metastasis 26(3):229-237(2009)

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$ 80.00
Cat# BP19387a
(40 western blots)
Availability: In Stock
Bulk Size
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