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BRMS1 Antibody(N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9HCU9 |
|---|---|
| Clone Names | 100525248 |
| Gene ID | 25855 |
|---|---|
| Other Names | Breast cancer metastasis-suppressor 1, BRMS1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | BRMS1 |
|---|---|
| Function | Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. |
| Cellular Location | Nucleus. Cytoplasm. Note=Predominantly nuclear. |
| Tissue Location | Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene reduces the metastatic potential, but not thetumorogenicity, of human breast cancer and melanoma cell lines. Theprotein encoded by this gene localizes primarily to the nucleus andis a component of the mSin3a family of histone deacetylasecomplexes (HDAC). The protein contains two coiled-coil motifs andseveral imperfect leucine zipper motifs. Alternative splicingresults in two transcript variants encoding different isoforms.
References
Wu, Y., et al. Cancer Lett. 293(1):82-91(2010)Vaidya, K.S., et al. Cancer Lett. 281(1):100-107(2009)Frolova, N., et al. Tumour Biol. 30(3):148-159(2009)Martins-de-Souza, D., et al. BMC Psychiatry 9, 17 (2009) :Cicek, M., et al. Clin. Exp. Metastasis 26(3):229-237(2009)
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