|Other Names||Retinoblastoma-like protein 1, 107 kDa retinoblastoma-associated protein, p107, pRb1, RBL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys- 20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.|
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The protein encoded by this gene is similar in sequenceand possibly function to the product of the retinoblastoma 1 (RB1)gene. The RB1 gene product is a tumor suppressor protein thatappears to be involved in cell cycle regulation, as it isphosphorylated in the S to M phase transition and isdephosphorylated in the G1 phase of the cell cycle. Both the RB1protein and the product of this gene can form a complex withadenovirus E1A protein and SV40 large T-antigen, with the SV40large T-antigen binding only to the unphosphorylated form of eachprotein. In addition, both proteins can inhibit the transcriptionof cell cycle genes containing E2F binding sites in theirpromoters. Due to the sequence and biochemical similarities withthe RB1 protein, it is thought that the protein encoded by thisgene may also be a tumor suppressor. Two transcript variantsencoding different isoforms have been found for this gene.
Jayadeva, G., et al. J. Biol. Chem. 285(39):29863-29873(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)
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