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MBD4 Antibody(Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O95243
Clone Names 100517290
Peptide ID 100517290
Additional Information
Gene ID 8930
Other Names Methyl-CpG-binding domain protein 4, 322-, Methyl-CpG-binding endonuclease 1, Methyl-CpG-binding protein MBD4, Mismatch-specific DNA N-glycosylase, MBD4, MED1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MBD4
Synonyms MED1
Function Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
Cellular Location Nucleus.
Research Areas
Citations (0)

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DNA methylation is the major modification of eukaryoticgenomes and plays an essential role in mammalian development. Humanproteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family ofnuclear proteins related by the presence in each of a methyl-CpGbinding domain (MBD). Each of these proteins, with the exception ofMBD3, is capable of binding specifically to methylated DNA. MBD4may function to mediate the biological consequences of themethylation signal. In addition, MBD4 has protein sequencesimilarity to bacterial DNA repair enzymes and thus may have somefunction in DNA repair. Further, MBD4 gene mutations are detectedin tumors with primary microsatellite-instability (MSI), a form ofgenomic instability associated with defective DNA mismatch repair,and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.


Arora, M., et al. Leukemia 24(8):1470-1475(2010)Thyagarajan, B., et al. Biol. Blood Marrow Transplant. 16(8):1084-1089(2010)Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)

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$ 80.00
Cat# BP19391c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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